Any personal meanings we create in life are all neutral as they all come from the exact same functions of our brains that create nothing but neutral words, sounds, images, etc. For example, create any sound, letter, image, etc. in your mind that provokes no emotional response and is bland to you. Therefore, all other meanings we create in life are the same in that sense because, again, they are all the same functioning in our brains. So that makes our own created meanings all neutral as well. These created meanings are no different than the creation of neutral words, sounds, images, etc. because there is no difference between any personal meanings we create in life as opposed to neutral words, sounds, images, etc. because they are the exact same things. Our personal meanings we create in life may make us do good things in life, but they are all still neutral anyway. Only our pleasure itself that arises from any personal meanings we create in life is good (positive) and is the only thing that makes our lives good and worth living and you would be delusional to somehow think that, without your ability to experience pleasure, that your life is still somehow good and worth living. Also, pleasure, in of itself, is a good experience and we do not need any created meanings in life (which would be knowledge, thoughts, etc.) to tell us that it is good. So if you were happy, but had no knowledge or thoughts whatsoever, your happiness would still feel good to you despite the fact that you are completely unaware of what happiness is and the fact that you are unaware of the word "good" and what it even means. Therefore, any created meanings in life by themselves do not tell us that anything is good (they are not the activating of the pleasure centers of our brains which is the only thing that gives us the "good" signal). The same thing goes for depression. Depression in of itself is a bad experience and we do not need any knowledge or thoughts to tell us that it is bad.